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Stern N, Gacs A, Ttrai E, Flachner B, Hajd I, Dobi K, et al

Investigations have sought an explanation of this variation and have suggested that the major resistance mechanisms include reduction in drug levels that reach the target DNA due to reduced uptake and/or increased efflux

Here are the cheapest options we found: Lower dose vitamin B12 tablets (10mcg) Vitamin Store Vitamin B12 (2 for 180 tablets) at Savers and Wilko = 1p per daily dose Superdrug Energy vitamin B12 (2.99 for 60 tablets, 5p per tablet, Superdrug) = 5p per daily dose Boots Vitamin B12 (3.20 for 60 tablets, 5p per tablet, Boots) = 5p per daily dose There is also a spray which gives 10mcg per two sprays (VitSpritz vitamin B12 oral spray, 9.95 for 30ml, Sainsbury's) but it costs more per dose = 8.6p per daily dose Higher dose vitamin B12 (1200mcg) Many of these are spray formats: Better You B12 Boost oral spray 1200mcg (9.90 for 25ml, Tesco) Four sprays gives 1200mcg of B12 = 20p per daily dose

DOI: 10.3390/ijms24032560 32