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A standard intravenous N-acetylcysteine protocol was started with 150 mg/kg of N-acetylcysteine mixed in 12 mL of 5% dextrose (3 mL/kg) and infused over 60 minutes, followed by 50 mg/kg of N-acetylcysteine mixed in 40 mL of 5% dextrose (10 mL/kg) and infused over 4 hours, then 100 mg/kg of N-acetylcysteine in 80 mL of 5% dextrose (20 mL/kg) infused over 16 hours

10.1371/journal.pone.0158498 PLoS One 115 MartinezI.Maldonado-GomezM

When present at such high serum concentrations, vitamin C generates cytotoxic reactive oxygen species, such as hydrogen peroxide

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