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Statistical analysis using an unpaired two-tailed t-test showed that there was a significant difference in the plasma concentrations of 2B3-101 and PEG-lipo-DOX (p = 0.021) 4 days after administration, but not in the brain concentrations (p = 0.052), and not in the brainplasma ratios (p = 0.29)

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This loss of neurons and diminished synaptic connectivity is particularly apparent in the hippocampus (Gao et al., 2011