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Notably, oral administration led to a measurable exchange of tritium with hydrogen in body water within 3 h, a phenomenon absent after intravenous dosing ( In addition, dietary components can significantly affect the absorption and overall bioavailability of EC by altering gastrointestinal conditions or interacting directly with the compound

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Finally, curcumin has also the ability to regulate autophagy, reducing the expression of key autophagy-related genes such as Beclin-1, ATG5, and LC3II, while increasing B cell lymphoma 2 (bcl-2), thereby improving colitis [509]

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