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[DOI] [PubMed] [Google Scholar] 1139.Leonard B.E

However, the last step of AsA synthesis is linked with a mitochondrial-localized enzyme called l-GalL dehydrogenase (l-GalLDH, EC 1.3.2.3) (Wheeler et al., 2015)

Research has shown that MT1G plays a crucial role as a tumor suppressor in pancreatic cancer stem cells

Conversely, integrase strand transfer inhibitors (INSTIs) such as Dolutegravir and Raltegravir are generally considered to have the most favorable mitochondrial safety profile, with little evidence of direct mtDNA toxicity