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[61] provided a final proof of concept

PCSK9 monoclonal antibodies (mAb) have become an important treatment for patients with hypercholesterolaemia for both primary and secondary prevention of cardiovascular disease (see Supplementary data online, Table S1 )

Since L-dopa is converted to dopamine in the CNS and the peri phery, peripheral conversion and systemic effects can be reduced by combining L-dopa with carbi dopa (a peripheral decarboxylation inhibitor), which does not cross the bloodbrain barrier