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The design of novel therapeutic agents such as monoclonal antibodies (mAbs), stem cells and genes is currently under way and clinical trials have been attempted, however, the therapeutic efficacy has been greatly limited by the fact that large molecular agents cannot penetrate the blood-brain barrier (BBB)

Vial count assumes a typical research draw of 20-40 units/day

An update on microfluidic multi-organ-on-a-chip systems for reproducing drug pharmacokinetics: the current state-of-the-art

For future studies, it would be of additional value to study treatment outcome prospectively by using standardized questionnaires, examinations, serologic follow-up, and neuropsychological assessments