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GSH inhibits PSC activation induced by high glucose via the ROS/TGF/SMAD pathway in vitro The above results indicated an increase in pancreatic fibrosis in rats treated with LOsG, which was accompanied by an increase in ROS/TGF/SMAD signalling, and PSC proliferation and activation, which were all prevented by GSH

By influencing melanin transport and activity, SLC24A5 enhances glutathiones whitening effect, delivering faster and more uniform results

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Although, there are other ROS, such as organic hydroperoxides (ROOH), peroxyl radical (ROO), alkoxyl radical (RO), singlet molecular oxygen ( 1 O 2 ), and ozone (O 3 ), that also play essential roles in signaling and disease (Sies and Jones, 2020)