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Regrettably, there have been reports of fatal side effects, including toxic epidermal necrolysis and Steven Johnson syndrome

on the other side, p53 directly inhibits the activity of DPP4 or induces the expression of CDKN1A/p21, to make it difficult for NOX1 to interact with DPP4 to form complexes, thus alleviating lipid peroxidation and ferroptosis (Tao et al., 2020)