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have suggested that the intervention of rosuvastatin in mice with HFD resulted in a significant increase in the Lachnospiraceae and Erysipelotrichaceae families and a significant decrease in Proteobacteria phylum, Coriobacteriaceae, Akkermansiaceae family, and Akkermansia (115)

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Reports across the 1980s described DSIP modulation of responses to morphine, amphetamine and barbiturates in rodents, with a profile generally interpreted as opioid-system modulation rather than direct opioid-receptor binding (Graf & Kastin, 1984)