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Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins

Genomic approaches to the deconvolution of microenvironmental cellular subtypes are increasingly utilised in oncology research

Using chemical inhibitor and KO mice, c-Jun amino-terminal kinase 2 (JNK2) was demonstrated to play a major role in morphine- but not fentanyl-induced G protein uncoupling (Melief et al., 2010)