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Melatonin has documented anti-inflammatory and immunomodulatory effects, including inhibition of NF-kB and modulation of mast cell function

Therapies that partially inhibit FAO or enhance substrate flexibility, such as trimetazidine or perhexiline, have shown benefits in small clinical trials, suggesting that modulation rather than maximization of FAO may be the optimal strategy (Tuunanen et al., 2008

Liu Q, Guan Y, Li S

Luciferin detection reagent (LDR) (100 l) was added to all wells, briefly shaken and incubated for 15 min at room temperature and the luminescence measured using microplate imager (BioTek Cytation3)