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ROS induce oxidative dimerization of the HIF prolyl hydroxylase, leading to its inactivation and HIF stabilization [52]

Ubiquitination comprises a multilayered biochemical machinery with E1 activating, E2 conjugating enzymes, E3 ubiquitin ligases, deubiquitinases, and a robust ubiquitin code 30 , as well as an ever-growing molecular repertoire of ubiquitinated molecular species 31

DOI: 10.1210/jcem-30-1-85 21

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