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Whether the results seen in animal pre-clinical models can be repeated in humans has been discussed previously [37, 38]

doi: 10.1093/bioinformatics/btac467 79 Saoudi GonzlezNJimnez SnchezARuiz de GaribayGSnchez NavarroAVidezALozanoMDSanmamedMFet al

Increased expression of UCP3 is associated with increased oxygen use and reduced cardiac efficiency in dietary models of obesity.48 The detrimental processes activated by mitochondrial dysfunction occur in addition to damage by lipotoxic products from the accumulation of triglycerides