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The 8mg dose achieved 21.1% weight loss (matching Zepbounds efficacy) with lower side effects: 24% nausea versus 28% at 12mg, 8.4% discontinuation versus 11.2%

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Grabarevic Z, Tisljar M, Artukovic B, et al

In the current study, the ratio of Firmicutes to Bacteroidetes was significantly higher in WD control mice compared to both groups of mice transitioned from WD to LD (Fig