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developed SIMS imaging to explore the uptake and subcellular localization of iron in alveolar macrophages, providing discernment and therapeutic strategies on iron metabolism at the subcellular level to reduce the cytotoxicity of iron overload [228]

Genetic variations play a significant role in drug kinetics and dynamics

At the genetic epidemiology level, Mendelian randomization-based analyses provide support for causal relationship hypotheses, though evidence strength remains preliminary (155)

The affinity of ATP for the GTP site appears to be 1000-fold lower than for GTP, since the - and -phosphate interactions are the major determinant of binding at the GTP site