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Description

In the brain, mHTT causes neuronal dysfunction and death through various mechanisms including formation of abnormal protein aggregates and disruption of proteostasis, and resulting impairments in synaptic, mitochondrial, and axonal transport functions

However, HepG2 cells exposed to a combination of fatty acids exhibited a marked increase in GR gene expression (Longhitano et al

Hepatic stellate cell activation and pro-fibrogenic signals

Combinatorial strategies, such as resveratrol with Citrus limon (L.) Osbeck peel extract, have been proposed to enhance efficacy through synergistic inhibition of apoptotic signaling pathways like iNOS/caspase-3 (Mobasher et al., 2022)