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[5] Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R

Some of the most important hormones that affect mental well-being include: Testosterone: Low levels in men (and women) are linked to fatigue, irritability, and depression

Genetics + Folate: When Leucovorin or 5-MTHF Matters Folate in the Brain : Folate enters the brain via folate receptor-alpha (FR) in the choroid plexus