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75 A small controlled trial with 23 participants suffering from chronic tinnitus found tailor-made notched music training reduced activity in auditory brain regions and tinnitus loudness more effectively than placebo music training (with a varying notch in frequency range) or no treatment after six months and one year

If folate deficiency is suspected, it is reasonable to give oral folic acid (0.4 1 mg/day) without doing laboratory investigation for deficiency at least until the hemoglobin and mean corpuscular volume normalizes (or longer if the underlying cause cannot be eliminated)

Improving levels may help emotional stability and wellbeing. 9

Contraindications include Leber's optic neuropathy and certain hematologic conditions