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While the role of lipid-uptake by MM cells and any functional consequences is unclear, recent studies demonstrate that myeloma-associated bone marrow adipocytes undergo lipolysis, associated with the uptake of secreted free fatty acids by adjacent MM cells (69, 70, 72)

Additionally, the harsh acidic environment of the stomach and/or dysfunctions in R-proteins (haptocorrins) that protect B12 in the stomach, and potential degradation by gastric enzymes can compromise the stability and bioavailability of oral B12 supplements

Y.et al (2019)

Clinical trials with platinum drugs Despite the increasing exploration of alternative therapies, hundreds of studies published last year alone highlight ongoing clinical trials using platinum-based drugs, typically in combination with other treatments, for cancer therapy