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This apparent discrepancy is not uncommon for this type of compound as similar results have been previously reported for ellagic acid, which displays 100 fold higher potency against parasites than against the purified GST enzyme, with a Ki of 74 M in an enzyme assay but an EC 50 of 0.8 M in antiparasitic assays (Sturm et al., 2009)

All findings are preclinical or from limited clinical trials and are presented here for educational reference only

On the first day, participants were given glucose solution (50 g glucose dissolved in 250 mL clean drinking water) and blood glucose readings were taken for 2 h, subsequently, the test food (quantity equivalent to 50 g carbohydrate) was administered to the participants according to their group stated as follows: Normal control (NC): non-diabetic healthy subjects Group 1 (G1): diabetic subjects not administered with any test food (CTRL) Group 2 (G2): diabetic subjects fed with multigrain snack bar from blend 1 comprising 90% amaranth, 5% acha, 5% pearl millet (MBY) Group 3 (G3): diabetic subjects fed with multigrain snack bar from blend 2 comprising 47.98% amaranth, 26.68% acha, 25.34% pearl millet (MBZ) Group 4 (G4): diabetic subject fed with commercial oat snack bar (COB) The test food was consumed within 15 min along with 75 cL of drinking water

CCl 4 administration causes reactive metabolites and oxidative stress, resulting in hepatocellular necrosis and liver failure