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prioritize event-driven hard outcomespatient-important events such as all-cause death, MACE (major adverse cardiovascular events), kidney failure, or fracture, with follow-up continuing until a prespecified event count is reachedand incorporate immune and epimeric markers to link biologic responses with clinical endpoints

flavonoids protect against pathological cardiac hypertrophy by inhibiting the Raf/MEK/ERK pathway: In vivo and in vitro studies

Nonetheless, targeting the FABP5GPX4 axis could represent a novel adjunct strategy to potentiate current biologics, reduce required dosages, and mitigate side effects

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