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These changes corresponded with lower oxidative damage and inflammatory burden in the nigrostriatal pathway

In this work, we aim to provide a comprehensive review of IGF-1 signaling in health and disease, including the most recent proposals regarding its context-dependent actions and important areas that require further study, as our current understanding of IGF-1R pathways remains limited

The disease affects the brain, spinal cord, heart, muscles, and beta () cells of the pancreas, thereby characterising the disease by progressive neurodegeneration, musculoskeletal deformities, diabetes mellitus and hypertrophic cardiomyopathy ( FXN gene ( FXN gene codes for a very important mitochondrial protein called frataxin (Weng et al., 2020)