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It is known that these chaperones can interact with key proteins in apoptotic signaling pathways (such as caspases) and regulate the nuclear factor-kappa B (NF-B) pathway and tumor necrosis factor (TNF)-mediated signal transduction, ultimately protecting cells and reducing heat stress-induced cell death [15]

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By pretreating with a nanoprimer before LNPs loaded with RNA therapeutics, the bioavailability of RNA-loaded LNPs significantly improved (Saunders et al., 2020)