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Hikosaka et al

In leaky gut syndrome, the immune system is activated, leading to inflammation and immune dysregulation, contributing to autoimmune conditions, metabolic disorders, inflammatory pain, and chronic infections

Furthermore, clinicopathological and microenvironment features were compared between the high- and low-risk patients

The potential effectiveness of anti-inflammatory treatment is further exemplified by a lowered risk for developing PD in patients receiving immunosuppressive therapy (111)