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There is little indication of giving the anti-dote before 8 hours.

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Reducing intestinal barrier permeability attenuates arthritis Since our results suggested that increased zonulin levels along with impaired intestinal permeability for lactulose and FITC-Dextran (FD4) are preceding the onset of murine and human arthritis, we sought an intervention that strengthens the intestinal barrier and may disrupt the transition from autoimmunity to inflammation and thereby inhibit the onset of arthritis

Inclusion criteria required studies to be published in English, to report original experimental or observational data (human or animal) on exercise-induced changes in immune parameters, and to clearly define the type and intensity of exercise involved