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At the species level, there was an increase in the abundance of Intestinibacter sp900540355 , Phocaeicola plebeius , Pseudoruminococcus massiliensis , Rikenella microfusus , Barnesiella intestinihominis , CAG-452 sp000434035 , Bacteroides fragilis , Turicibacter sanguinis , and Alistipes communis and decrease in the Bariatricus comes , Faecalibacterium prausnitzii , Intestinimonas butyriciproducens , Parvimonas sp001553085 , Gemella morbillorum and Finegoldia magna [208]

A significant increase in midazolam exposure (respectively from 3.02-fold to 26.41-fold for AUC and from 1.15-fold to 4.27-fold for C max ) in healthy volunteers concomitantly treated with ritonavir alone or ritonavir-boosted PIs has been reported, caused by strong inhibition of CYP3A4 [92,93,94,95]

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Finally, through multicenter, large-sample clinical cohort studies combined with statistical methods, derive and validate clinically meaningful cutoff values to enable precise patient stratification and individualized treatment