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Under normal conditions, there is a well-regulated equilibrium in the GI mucosa between inflammatory cytokines (such as TNF-, IL-1, IL-6, IL-8, IL-17, and IL-23) and anti-inflammatory cytokines (like IL-5, IL-10, IL-11, and TGF-) (75)

Since GSH is the final product of the homocysteine metabolism in the transsulfuration pathway by transferring sulfur from homocysteine to cysteine, a deficiency in transsulfuration pathway leads to excessive homocysteine production (hyperhomocysteinemia) and reduced GSH synthesis (159, 160)

Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity

S.Cipolla-NetoJ.et al (2024)