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Common symptoms of mast cell diseases include skin rashes, unexplained flushing, stomach pain, gastrointestinal tract problems, nausea, bloating and bone or joint pain

In addition, in animal model studies, the enhancement of the activity of low-density lipoprotein receptor-related protein-1 (LRP1) and the inhibition of the expression of erythrocyte integrin-related protein CD-47 can enhance endogenous hematoma clearance (Tyler et al., 1999), not all hematoma removal show outcome benefit