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In addition, there is a higher susceptibility of Nrf2 -null mice to liver injury [42], while the semi-synthetic oleanane triterpenoid compounds that activate Nrf2 were shown to be hepatoprotective in different models of liver disease (nonalcoholic fatty liver disease, acetaminophen-induced liver injury, and immune-mediated hepatotoxicity) that have been tested [40, 43,44,45]

The body tightly regulates intracellular glutathione levels along with its synthesis from amino acid precursors

& Rost, J

Zhang et al., 2024) identify GPX4 as a key enzyme counteracting LPO in hippocampal neurons, closely linked to AD neurodegeneration