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Endogenous mechanisms involve changes in epigenetic modifications and the expression of related transcription factors, whereas exogenous mechanisms are primarily related to changes in the tumor microenvironment (TME), such as hypoxia, infiltration of tumor-promoting immune cells, and the release of pro-inflammatory factors [173]

(2) One patent pending: Lipidomic approaches for central nervous system disorders Application # 12/091,213 filed 12/10/08, Publication # US 2009/0305323 12/10/09.] All other authors declare no conflict of interest

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The absence of standardized diagnostic criteria further contributed to substantial underdiagnosis or delayed recognition, especially for nontremor or atypical presentations [46]