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In addition, we accessed databases of ongoing trials including ClinicalTrials.gov ( the EU Clinical Trials register ( and the World Health Organization (WHO) International Clinical Trials Registry Platform Search Portal ( Major monogenic disorders requiring lifelong or decades of therapy Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder characterized by severely elevated low-density lipoprotein cholesterol (LDL-C) levels of above 10.3 mmol/L (400 mg/dL), leading to cutaneous and tendon manifestations, such as xanthelasmas and xanthomas, as well as premature ASCVD that often begins in childhood

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and glutaredoxins, which use GSH to repair oxidised protein thiols