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Parker L, Padilla M, Du Y, Dong K, Tanouye MA (2011) Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures

Half of the dose (with some excess) was given in a canister at visit 4 after randomization

39 Similarly, treatment with once-weekly retatrutide 12 mg for 48 weeks resulted in a 24.2% mean weight reduction compared with 2.1% for placebo, with 83% of participants achieving 15% weight loss