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Ageing Research Reviews, 3 (4), 407430

According to the NCCN ( Figure 1 Histologic confirmation of disease: This includes a confirmed diagnosis of grade 1, endometrioid adenocarcinoma limited to the endometrium (Stage IA), or AEH, based on endometrial ( Absence of myometrial invasion or metastasis: Imaging studies (MRI preferred) should confirm that the disease is confined to the endometrium, with no evidence of myometrial invasion, cervical involvement, or distant metastasis ( Patients should have no contraindications to hormonal therapy: This includes evaluating the patients medical history for contraindications to progestins or other hormonal treatments ( Strong patient commitment to follow-up: Patients need to be highly compliant with close follow-up, as fertility-preserving treatment requires ongoing monitoring of the disease ( The cornerstone of fertility-preserving treatment in both AEH and early-stage EC is hormonal therapy

4 Conclusions and challenges Targeted pathways are crucial for preventing chronic inflammatory diseases, reducing patient adverse reactions, and improving cure rates