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More recently, spinocerebellar ataxia type 2 has also been linked to the presence of a transition polymorphism in the GSTO2 gene (rs2297235 A183G) which significantly correlates with the age at disease onset

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If translation is initiated from the first start codon, then Glr1 is encoded with a mitochondrial matrix targeting sequence, while translation from the second start codon leads to a shorter cytosolic protein (Outten and Culotta, 2004)