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Perfluorooctanoic acid (PFOA) has a damaging effect on the liver, and vitamin C supplementation can reduce PFOA-induced total cholesterol and triglyceride levels and reduce abnormal enlargement of the liver, mainly by inhibiting linoleic acid metabolism and increasing glutathione in the liver (128)

CCl 4 administration causes reactive metabolites and oxidative stress, resulting in hepatocellular necrosis and liver failure

Quantitative RT-PCR Total RNA was extracted using PureLink RNA isolation (Life Technologies, 12183025) and treated with DNase (Life Technologies, AM2222)

Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome