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Description

Engineered Cas9 cleaves the DNA in a sequence-specific mode and creates a specific double-stranded break, so the cell can fill the excised portion with the correct gene sequence

Meanwhile, Tph2 is significantly upregulated in the core region of colorectal cancer tumors, and conditional knockout of Tph2 in intestinal epithelial cells markedly suppresses tumorigenesis in a murine intestinal cancer model (203)