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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Hayhurst GP, Lee YH, Lambert G, et al

CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPAR expression

This copper overload can cause damage to the liver, nervous system, and other organs, with the liver being the most significantly affected organ in patients (44)

Like the 6 -desaturase, the activity of the 5 -desaturase is limiting in arachidonic acid synthesis and its activity is also influenced by diet and environmental factors