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Percent discordance between estimated CKD stage and actual CKD stage was lower with GRAIL_NR in patients with ascites and females

When an oxygen molecule enters the active site, deoxy tyrosinase converts back to the oxidized tyrosinase state, completing the cycle

It is believed that they place a cationic residue near the key cysteine to ensure it is deprotonated, provide a cavity that orients H 2 O 2 for nucleophilic attack, polarize the oxygenoxygen bond that must be split, and provide a proton donor to stabilize the hydroxide product