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Hence, the results may be applicable to only young, otherwise healthy Asian individuals

Barton DJ, Kumar RG, Schuster AA, Juengst SB, Oh BM, Wagner AK

JAMA 331(5):425-435, 2024

In the GCH1-BH4-DHFR axis, BH4, synthesized by GCH1, acts as a potent lipophilic radical scavenger that selectively protects PUFA-PLs and regulates CoQ10 synthesis, while DHFR maintains BH4 recycling to enhance defense (44, 45)