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Landscapes Health & Medical Sciences (AREA) Life Sciences & Earth Sciences (AREA) Chemical & Material Sciences (AREA) Medicinal Chemistry (AREA) Pharmacology & Pharmacy (AREA) Animal Behavior & Ethology (AREA) General Health & Medical Sciences (AREA) Public Health (AREA) Veterinary Medicine (AREA) Epidemiology (AREA) Engineering & Computer Science (AREA) Bioinformatics & Cheminformatics (AREA) Emergency Medicine (AREA) Gastroenterology & Hepatology (AREA) Immunology (AREA) Proteomics, Peptides & Aminoacids (AREA) Chemical Kinetics & Catalysis (AREA) General Chemical & Material Sciences (AREA) Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA) Organic Chemistry (AREA) Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA) Abstract The present invention provides a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders, diseases, conditions, or drug- or surgery-induced dysfunction) of the gastrointestinal system, by administering to the subject a ghrelin mimetic, or pharmaceutically acceptable salt thereof

The SUSTAIN and STEP trial programs documented these changes across thousands of participants

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Through cleavage of dynamic phenylboronic ester bonds under ROS stimulation 62 , the hydrogel demonstrated ROS-sensitive drug release behavior, as evidenced by the 90% cumulative release of D-CuP within 72 h under H 2 O 2 stimulation (Fig