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This perspective, supported by the Lancet Commission on Dementia Prevention, Intervention and Care, is grounded in large-scale observational studies linking factors such as low educational attainment, midlife hearing loss, hypertension, obesity, smoking, depression, diabetes, physical inactivity, and social isolation to increased dementia risk (103)

These models allow for a systematic investigation of the differential effects of peripheral ApoE isoforms on brain function and AD pathology [85]

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