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A novel glycoengineered bispecific antibody format for targeted inhibition of epidermal growth factor receptor (EGFR) and insulin-like growth factor receptor type I (IGF-1R) demonstrating unique molecular properties

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1998) demonstrated dose-dependent GH release (ED50 ~80 nmol/kg), no cortisol or prolactin elevation, and a 24% increase in bone growth rate (52 vs 42 m/day) in rat models