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As previously described, employing an established drug approach led to the identification of 14 inhibitors against M pro from a virtual screen encompassing approximately 2000 known and approved drugs

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Macrophagesthe primary source of foam cellsproliferate in the arterial intima after pro-inflammatory activation by endothelial cells, allowing them to migrate across the endothelial barrier

In addition, the antioxidants 2-mercaptopropionyl glycine and 1,10-phenanthroline attenuated these increases and abolished the inhibition of contraction