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2014, 6, 202209 DOI: 10.1177/1758834014539183 N

The loss of a protein called caveolin-1 (Cav-1) in stromal fibroblasts can lead to NO overproduction and a metabolic shift toward aerobic glycolysis

PKl in kidney and liver

Targeting NRF2 in EC NRF2 act as a crucial regulator of antioxidant response, Its functions encompass the regulation of iron metabolism, management of exogenous substances, breakdown of reactive aldehydes and the synthesis of GSH and the regeneration of NADPH (Fig