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Both can be valuable when used correctly

2010;2(5) doi: 10.1042/AN20100019

However, during inflammatory reactions, exposure of macrophages to interferon (IFN) and TNF results in the activation of the inducible isoenzyme of NOS (iNOS), which increases up to 10 times the levels of nitric oxide

This results in chronic hypercortisolism, adrenocortical hyperplasia, glucose intolerance and mature-onset obesity, resembling human Cushings syndrome 64