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After 6 months, the rats were sacrificed, the blood sample collected and the kidneys harvested for evaluation of biochemical analytes, genes expression, and histopathological changes

doi: 10.1002/advs.202101222 13

Polyphenols are the most abundant secondary metabolites of plant origin, with potent antioxidant and anti-inflammatory effects, and can exert protective activity against a whole range of disorders

Mechanistically, ALC exerts its antidepressant effects via multiple pathways, including enhancement of mitochondrial function, upregulation of brain-derived neurotrophic factor (BDNF), modulation of glutamatergic neurotransmission, and epigenetic regulation of gene expression involved in mood regulation