Compared to normal tissue, GLO-1 was significantly upregulated in 28 tumors, including GBM (Tumor: 6.73 0.48, Normal: 5.37 1.31, p = 6.7e75), GBMLGG (Tumor: 6.58 0.41, Normal: 5.37 1.31, p = 8.5e216), LGG (Tumor: 6.53 0.37, Normal: 5.37 1.31, p = 3.7e178), BRCA (Tumor: 6.83 0.68, Normal: 5.37 1.31, p = 3.7e179), EGFR (Tumor: 6.83 0.68, Normal: 5.37 1.31, p = 3.7e179), CESC (Tumor: 6.44 0.63, Normal: 5.91 0.21, p = 1.2e4), LUAD (Tumor: 6.49 0.68, Normal: 5.87 0.93, p = 3.5e42), ESCA (Tumor: 6.78 0.62, Normal: 5.25 1.26, p = 6.3e84), STES (Tumor: 6.44 0.68, Normal: 5.13 1.38, p = 3.6e165), COAD (Tumor: 6.40 0.52, Normal: 4.99 1.67, p = 2.6e90), COADREAD (Tumor: 6.43 0.55, Normal: 5.01 1.66, p = 1.9e102), PRAD (Tumor: 7.81 0.90, Normal: 6.52 1.03, p = 4.7e34), STAD (Tumor: 6.29 0.65, Normal: 4.75 1.64, p = 6.8e64), HNSC (Tumor: 6.49 0.60, Normal: 5.72 0.54, p = 9.7e15), LUSC (Tumor: 6.52 0.66, Normal: 5.87 0.93, p = 9.2e48), LIHC (Tumor: 5.86 0.76, Normal: 4.87 0.60, p = 9.8e38), WT (Tumor: 7.21 0.38, Normal: 6.07 1.49, p = 3.5e35), SKCM (Tumor: 6.14 0.83, Normal: 5.78 0.39, p = 4.1e11), BLCA (Tumor: 6.13 0.74, Normal: 5.78 0.33, p = 1.3e3), THCA (Tumor: 5.64 0.43, Normal: 5.29 0.92, p = 7.8e28), READ (Tumor: 6.50 0.62, Normal: 6.02 0.34, p = 4.8e3), OV (Tumor: 6.59 1.08, Normal: 6.11 0.26, p = 5.6e14), PAAD (Tumor: 5.58 0.46, Normal: 3.62 1.58, p = 1.0e53), TGCT (Tumor: 6.01 0.89, Normal: 4.47 0.63, p = 1.3e37), and UCS (Tumor: 6.72 0.60, Normal: 5.74 0.29, p = 5.2e-18)
Black dots highlight proteins that meet both significance thresholds
Closely associated with cardiometabolic disease, NAFLD is an independent risk factor CVD (92) , and a prevalent co-morbidity of type 2 diabetes (93) , with recent estimates suggesting 4764 % of individuals with type 2 diabetes have NAFLD globally (94)
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