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PMID 14978193

These processes exacerbate Alzheimers disease progression and negatively impact cognitive function and emotional regulation ( Circulating microbial products: The entry of bacterial toxins to the bloodstream can stimulate immune responses and mimic host proteins, such as A, promoting molecular mimicry and immune activation (Leblhuber et al., 2021)

323 Fibroblast activation protein (FAP), also known as F19, a serine protease involved in ECM remodeling, is highly expressed in CAFs but virtually absent in normal fibroblasts or other normal tissues

Rather than positioning OSCs as stand-alone antimicrobials, we frame them as adjunctive agents with plausible utility in settings where conventional antibiotics show persistent limitationssuch as multidrug-resistant pneumonia, topical and device-associated biofilm infections, and gut-localized infections where high local exposure and immunomodulatory effects may be advantageous