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The structural distinction between Melanotan 1 and native -MSH is a single amino acid substitution replacement of the methionine residue at position 4 with a norleucine residue which eliminates methionines susceptibility to oxidative degradation and substantially improves the peptides metabolic stability and resistance to enzymatic breakdown

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[22] recently conducted a cross-sectional study in 1,081 participants in Newfoundland, Canada to determine correlations between serum carnitine levels and cardiovascular markers